5142-23-4 | 3-Methyladenine (3-MA)

Chemical type

• Autophagy inhibitor
• Small molecule PI3K inhibitor

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• Autophagy inhibitor

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Key properties

• Blocks autophagy by inhibiting class III PI3K
• Reduces SU11274-induced autophagic ratio, Beclin-1 expression, and LC3 conversion
• Decreases SU11274-mediated cell death, indicating protective role against autophagic cytotoxicity
• Used at millimolar concentrations (e.g., 0.4 mM)

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• Inhibits autophagosome formation
• Suppresses NF-κB signaling pathway
• Reduces IL-6 levels and macrophage recruitment
• Administered intraperitoneally at 10 mg/kg/day
• Alleviates colitis severity in aged models

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• Tool to inhibit autophagy in cancer research
• Agent to study autophagy's role in cell death and survival

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• Pharmacological treatment for DSS-induced colitis in aged mice
• Inhibits excessive autophagy in intestinal epithelial cells
• Mitigates inflammation in elderly ulcerative colitis models

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Classification by use

• Chemicals used as autophagy inhibitors
• Chemicals used in cell death mechanism studies

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• Chemicals used as autophagy modulators
• Chemicals used in anti-inflammatory therapy for IBD

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A trustworthy factory and manufacturer

1. [Cite:1] Activation of ERK–p53 and ERK-Mediated Phosphorylation of Bcl-2 Are Involved in Autophagic Cell Death Induced by the c-Met Inhibitor SU11274 in Human Lung Cancer A549 Cells, Journal of Pharmacological Sciences, Volume 118, Issue 4, 2012, Pages 423-432
2. [Cite:2] Autophagy inhibitor 3-methyladenine mitigates the severity of colitis in aged mice by inhibiting autophagy, Experimental Gerontology, Volume 201, March 2025, 112697