111-30-8 | Glutaraldehyde

Chemical type

• Dialdehyde Fixative

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• Chemical crosslinking agent

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• Dialdehyde cross-linking agent

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Key properties

• Stronger cross-linker than formaldehyde; preserves cellular ultrastructure more effectively for electron microscopy.
• Has better penetration and longer-lasting fixation.

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• Forms uniform network; enhances mechanical strength and flexibility; prevents thermal degradation during processing.

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• Reacts with N-terminal amino groups, α-amino groups of amino acids, and sulfhydryl groups of cysteine
• Forms complex high molecular-weight protein species
• Irreversible chemical modifications to proteins
• Causes structural changes, particularly in protein oligomers (e.g., more dramatic changes in B oligomer than A protomer of pertussis toxin)
• Reduces toxicity by modifying functional domains
• Alters antigenic properties and epitopes
• Effects influenced by concentration (0.05% to 1.0% w/v), buffer pH (6.0 to 9.0), incubation time (4 to 24 hours), and temperature (room temperature)

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• Used in combination with formaldehyde (in FAEG fixative) for SEM sample fixation.

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• Added (1% w/w) for in situ chemical crosslinking of Chit/PCL blends during cryogel fabrication.

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• Detoxification of pertussis toxin for acellular pertussis vaccines
• Inactivation of bacterial toxins by cross-linking subunits
• Protein fixation and modification in biochemical assays

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Classification by use

• Electron Microscopy Fixative
• Histological Fixative

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• Crosslinking agents in polymer scaffolds
• Chemicals for structural stabilization in biomaterials

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• Chemicals used in vaccine production

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A trustworthy factory and manufacturer

1. [Cite:1] Floral ontogeny and development of the model plant Nicotiana benthamiana, Current Plant Biology, Volume 45, January 2026, 100578
2. [Cite:2] Bioactive chitosan/polycaprolactone cryogel sponge co-loaded with ciprofloxacin and ginger for controlled drug release and healing of infected wounds, Materials & Design, Volume 259, November 2025, 114913
3. [Cite:3] Glutaraldehyde modifies the catalytic and binding subunits of pertussis toxin, affecting its toxicity and immunogenicity, Vaccine: X, Volume 27, December 2025, 100732