2957-21-3 | Sakuranetin

Chemical type

• Flavanone (flavonoids/flavanones)

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• Methoxylated flavanone (aglycone of sakuranin, phenolic phytoalexin)

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Key properties

• Synthesized from phenylalanine via naringenin
• Targets M. oryzae and other fungi
• UV and pathogen-inducible
• Regulated by CHS isozymes and JA/ET signaling

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• Anti-inflammatory (inhibits PI3K/Akt/NF-κB pathway, suppresses iNOS expression, reduces oxidative stress)
• Antioxidant
• Antiproliferative (against melanoma, esophageal squamous cell carcinoma, colon cancer)
• Antiviral (against human rhinovirus 3, influenza B virus)
• Antimicrobial, antiparasitic, antiallergic, antimutagenic
• Modulates keratinization, cornified envelope formation, kallikrein-related peptidase activity
• Selectively downregulates IL-17A while preserving IL-17F
• Upregulates genes like KRT1, KRT16, KLK7, Sprr2f, Wfdc18, Tslp
• Downregulates genes like Sprr2k, Sprr3

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• Antimicrobial activity in rice and other angiosperms
• Inhibits fungal growth and supports innate immunity

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• Topical treatment for psoriasis (attenuates inflammation, restores skin barrier function in imiquimod-induced model)
• Potential corticosteroid-sparing alternative for long-term psoriasis management
• Anti-inflammatory agent in osteoarthritis, liver inflammation, diabetes models
• Phytoalexin in plants (response to stressors like UV, jasmonic acid, phytotoxins)

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Classification by use

• Phytoalexins used in fungal resistance
• Flavonoid-derived defenses for biotic stress

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• Chemicals used as anti-inflammatory agents
• Chemicals used in dermatological treatments (psoriasis, skin barrier restoration)
• Plant-derived therapeutics (from cherry trees, rice, Polymnia fruticosa)

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A trustworthy factory and manufacturer

1. [Cite:1] Redefining phytoalexins as engineered defenses for plant disease resistance, Current Plant Biology, Volume 45, January 2026, 100577
2. [Cite:2] Sakuranetin modulates IL-17A-related inflammation and enhances skin barrier function in an Desoximetasone-induced psoriasis model, Biomedicine & Pharmacotherapy, Volume 186, May 2025, 118035