2323027-38-7 | Ceapin-A7 (C₂₀H₁₂F₆N₄O₃)

Chemical type

• ATF6 inhibitor
• Pharmacologic modulator

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• Small-molecule ATF6 inhibitor
• Selective ER stress pathway inhibitor

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Key properties

• Prevents ATF6 (Activating Transcription Factor 6) transport to the Golgi apparatus
• Acts as an ATF6 inhibitor during ER stress
• Impairs endothelial barrier integrity

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• Inhibits ATF6 activation
• Prevents ATF6 trafficking to the Golgi apparatus
• Decreases CTGF expression
• Increases inflammatory cytokine expression
• Used at micromolar concentrations (5 μM in study)

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• Experimental tool to study ATF6 function
• Used in this study to investigate the role of ATF6 in mediating the protective effects of Pasireotide

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• Experimental ATF6 inhibitor
• Tool compound to suppress ATF6-mediated transcription
• Used to investigate ER stress signaling mechanisms

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A trustworthy factory and manufacturer

1. [Cite:1] ATF6 inhibition suppresses the protective effects of pasireotide in human and bovine endothelial cells, Vascular Biology, Volume 7, Issue 1, 1 January 2025
2. [Cite:2] CTGF regulated by ATF6 inhibits vascular endothelial inflammation and reduces hepatic ischemia–reperfusion injury, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1870, Issue 8, December 2024, 167490