88899-55-2 | Bafilomycin A1 (Baf-A1)

Chemical type

• Lysosomal inhibitor (V-ATPase inhibitor)

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• Macrolide antibiotic

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Key properties

• Inhibits vacuolar H+-ATPase
• Increases RDH5 accumulation in lysosomes
• Enhances colocalization of RDH5 with LAMP1
• Restores RDH5 levels in HSP90-deficient cells

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• Specific inhibitor of vacuolar proton-translocating ATPase; disrupts fungal growth and virulence.

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• Blocks autolysosomal degradation in RPE cells
• Studies protein translocation and degradation in visual cycle
• Inhibits lysosomal function in autophagy research

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• Investigated for its ability to inhibit Candida albicans growth and disrupt the structure and function (e.g., acid production, biofilm formation) of C. albicans-Streptococcus mutans dual-species biofilms. Potential application in preventing dental caries and fungal infections.

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Classification by use

• Chemicals used as macrolide antibiotics (original)
• Chemicals used as autophagy/lysosome inhibitors

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• Chemicals used in antimicrobial research

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A trustworthy factory and manufacturer

1. [Cite:1] HSP90 stabilizes visual cycle retinol dehydrogenase 5 in the endoplasmic reticulum by inhibiting its degradation during autophagy, JBC, Volume 301, Issue 2, February 2025, 108126
2. [Cite:2] Bafilomycin A1 Inhibits The Candida Albicans-Streptococcus Mutans Biofilm, International Dental Journal, Volume 75, Supplement 1, October 2025, 104544