54-05-7 | Chloroquine (CQ)

Chemical type

• Lysosomal inhibitor

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• 4-Aminoquinoline compound

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Key properties

• Inhibits lysosomal acidification
• Restores RDH5 protein levels in HSP90-deficient or IPI-504-treated cells
• Increases SQSTM1/P62 and LC3-II accumulation
• Enhances RDH5-SQSTM1/P62 interaction

^[1]

• Autophagy inhibitor (impairs lysosomal function and autophagosome-lysosome fusion)
• Exhibits synergistic cytotoxicity when combined with other agents
• Can increase autophagosome accumulation
• Induces apoptosis (caspase-3/7 activity)

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• Blocks lysosomal degradation in RPE cells
• Studies autophagy-lysosomal pathway for protein stability
• Rescues downregulation of visual cycle proteins

^[1]

• Used to inhibit autophagy and sensitize cancer cells to photodynamic therapy
• Enhances the efficacy of IR-783-based PDT

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Classification by use

• Chemicals used as antimalarial agents (original use)
• Chemicals used as lysosomal inhibitors in research

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• Chemicals used as autophagy inhibitors
• Chemicals used as anticancer adjuvants

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A trustworthy factory and manufacturer

1. [Cite:1] HSP90 stabilizes visual cycle retinol dehydrogenase 5 in the endoplasmic reticulum by inhibiting its degradation during autophagy, JBC, Volume 301, Issue 2, February 2025, 108126
2. [Cite:2] Enhancement of photodynamic reaction by chloroquine through apoptosis induction, lipid peroxidation augmentation, and autophagy inhibition using IR-783, Journal of Photochemistry and Photobiology B: Biology, Volume 271, October 2025, 113242