199062-33-4 | Pertussis Toxin

Chemical type

• Bacterial protein toxin (from Bordetella pertussis)

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• Bacterial protein toxin

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• Bacterial toxin
• Gαi protein inhibitor

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Key properties

• Enhances autoimmune response by disrupting blood-brain barrier
• Administered intraperitoneally at 200 ng dose
• Facilitates CNS infiltration by immune cells in EAE
• Contributes to EAE symptom onset and severity

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• ADP-ribosylates G proteins, disrupts blood-brain barrier integrity, enhances immune cell infiltration into the CNS, increases EAE disease severity in a concentration-dependent manner

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• ADP-ribosylates Gαi subunits
• Inhibits Gαi-mediated signaling
• Did not affect (R)-(-)-carvone-evoked calcium responses

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• Adjuvant in EAE induction protocol
• Tool for modeling neuroinflammatory diseases like MS
• Administered on day of immunization to potentiate encephalitogenic effects

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• Adjuvant to supplement MOG and CFA in inducing EAE models of multiple sclerosis, promotes autoimmune encephalomyelitis pathology

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• Research tool for identifying Gαi involvement
• Inhibitor in GPCR signaling studies

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Classification by use

• Chemicals used as toxins in disease models
• Chemicals used in immunological adjuvants
• Chemicals used in autoimmune research

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• Immunomodulatory agents in preclinical autoimmune disease models

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• Bacterial toxins
• G protein inhibitors

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A trustworthy factory and manufacturer

1. [Cite:1] Mitogen-activated protein kinase inhibitor PD98059 improves neuroimmune dysfunction in experimental autoimmune encephalomyelitis in SJL/J mice through the inhibition of nuclear factor-kappa B signaling in B cells, Brain Research Bulletin, Volume 194, March 2023, Pages 45-53
2. [Cite:2] EAE models of neuropathic pain in multiple sclerosis do not require pertussis toxin, Brain Research, Volume 1875, 15 March 2026, 150162
3. [Cite:3] The odorant (R)-(-)-carvone promotes glucose-stimulated insulin secretion via the olfactory receptor Olfr1259 in pancreatic β-TC6 cells, Archives of Biochemistry and Biophysics, Volume 768, June 2025, 110404