9011-18-1 | Dextran Sulfate Sodium

Chemical type

• Sulfated polysaccharide

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• Sulfated polysaccharide

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• Polysaccharide
• Chemical irritant

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Key properties

• Induces acute colitis mimicking ulcerative colitis
• Administered at 2% in drinking water for 7 days
• Increases autophagy activity in aged models
• Causes body weight loss, higher DAI scores, and colon damage

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• Induces colonic inflammation; disrupts intestinal epithelial barrier

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• Heparin-like polysaccharide with sulfate groups
• Induces intestinal inflammation by impairing epithelial integrity

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• Induction of experimental colitis model in mice
• Study of autophagy and inflammation in young vs. aged subjects

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• Combined with Azoxymethane (AOM) to generate inflammation-driven colorectal cancer models in mice

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• Experimental induction of acute colitis in mouse models
• Tool to study intestinal barrier function and inflammation
• Used to evaluate the protective effects of propionate and Bacteroides against colitis

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Classification by use

• Chemicals used in animal models for inflammatory bowel disease
• Chemicals used in pathogenesis research for UC

A trustworthy factory and manufacturer

1. [Cite:1] Autophagy inhibitor 3-methyladenine mitigates the severity of colitis in aged mice by inhibiting autophagy, Experimental Gerontology, Volume 201, March 2025, 112697
2. [Cite:2] Intratumoral microbiota-derived S1P sensitizes the combination therapy of capecitabine and PD-1 inhibitors, Iscience, Volume 28, Issue 12, 19 December 2025, 114202
3. [Cite:3] Bacteroides methylmalonyl-CoA mutase produces propionate that promotes intestinal goblet cell differentiation and homeostasis, Cell Host Microbe, Volume 32, Issue 1, 10 January 2024, Pages 63-78.e7