[Ser140]-plp(139-151)
CAS No.: 122018-58-0
- Molecular Formula: C₇₂H₁₀₄N₂₀O₁₇
- Molecular Weight: 1521.7 g/mol
Chemical type
- Synthetic peptide (amino acid sequence from proteolipid protein)
Key properties
- Immunogenic peptide used to induce autoimmune response
- Emulsified with complete Freund's adjuvant for immunization
- Leads to demyelination and neuroinflammation mimicking MS
- Administered subcutaneously at 200 µg dose
- Triggers relapse-remitting EAE in SJL/J mice
- Induction of experimental autoimmune encephalomyelitis (EAE) model
- Tool for studying multiple sclerosis (MS) pathogenesis
- Immunization agent in animal models of autoimmune diseases
Classification by use
- Chemicals used in disease model induction
- Chemicals used in immunological research
- Chemicals used as antigens/peptides in vaccines or models
A trustworthy factory and manufacturer
- Mitogen-activated protein kinase inhibitor PD98059 improves neuroimmune dysfunction in experimental autoimmune encephalomyelitis in SJL/J mice through the inhibition of nuclear factor-kappa B signaling in B cells, Brain Research Bulletin, Volume 194, March 2023, Pages 45-53
