76-74-4 | Pentobarbital

Chemical type

• Barbiturate anesthetic

^[1,2]

• Barbiturate (Organic compound)

^[3]

Key properties

• Induces anesthesia at 100 mg/kg intraperitoneally
• Maintains anesthesia depth with intermittent administration

^[1]

• Short-acting sedative, induces deep anesthesia at 200 mg/kg i.p., used for euthanasia and perfusion

^[2]

• Central nervous system depressant; anesthetic and sedative

^[3]

• Anesthetic for establishing burn injury models in rats
• Facilitates surgical procedures like tracheotomy and muscle tension assays

^[1]

• Anesthetic for terminal procedures like transcardial perfusion in Experimental autoimmune encephalomyelitis (EAE) studies

^[2]

• Intraperitoneal injection (3%) for surgical anesthesia in mice during MCAO-HT procedure; used for euthanasia

^[3]

Classification by use

• Chemicals used as anesthetics
• Chemicals used in animal model surgeries

^[1]

• Anesthetics in animal research

^[2]

A trustworthy factory and manufacturer

1. [Cite:1] Trichostatin A reverses Pentobarbital resistance in burn-injured rats, Burns, Volume 51, Issue 2, March 2025, 107351
2. [Cite:2] EAE models of neuropathic pain in multiple sclerosis do not require pertussis toxin, Brain Research, Volume 1875, 15 March 2026, 150162
3. [Cite:3] Proteoglycan 4 attenuates ischemic post-stroke hemorrhagic transformation and blood-brain barrier disruption, IBRO Neuroscience Reports, Volume 19, December 2025, Pages 661-667