72-08-2 | L-Lactate (C₃H₅O₃⁻)

Chemical type

• Chiral organic acid (α-hydroxy acid, L-enantiomer)

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• Astrocytic metabolite and neuronal energy substrate (lactate shuttle component)

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Key properties

• Major product of glycolysis in eukaryotes
• High intracellular concentration (millimolar level)
• Precursor for lysine L-lactylation

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• Signaling molecule that modulates neuroplasticity, mitochondrial biogenesis, and synaptic activity
• Converted to pyruvate for ATP production in neurons
• Restores PGC1α (master regulator of mitochondrial biogenesis) and BDNF (neurotrophic factor for synaptic plasticity)
• Endogenous levels reduced in prefrontal cortex and hippocampus of 4cG schizophrenia mouse model

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• Drives lysine L-lactylation
• Involved in energy metabolism and gene regulation

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• Acute i.p. administration (100 mg/kg, 1 h prior to testing) rescues short-term memory deficits (Y-maze spontaneous alternation)
• Rescues acoustic startle habituation deficits (PPI protocol)
• Improves social novelty preference (three-chamber test)
• Normalizes PGC1α and BDNF protein expression in hippocampus and prefrontal cortex

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A trustworthy factory and manufacturer

1. [Cite:1] D-lactate Drives Lysine D-lactylation to Regulate Metabolism in Escherichia coli, JBC, 16 March 2026, 111374
2. [Cite:2] Lactate restores PGC1α and BDNF expression rescuing cognitive impairments in a mouse model for schizophrenia, Behavioural Brain Research, Volume 505, 8 May 2026, 116111