528-48-3 | Fisetin

Chemical type

• Flavonol (flavonoid)

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• Natural flavonoid (Flavonol subclass)
• Plant-derived polyphenolic compound

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Key properties

• Reverses cognitive decline
• Targets Aβ plaque buildup, tau hyperphosphorylation, neuroinflammation, and oxidative stress

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• Antioxidant activity (ROS scavenger)
• Anti-inflammatory activity
• Anti-apoptotic activity
• Modulates PI3K/Akt/mTOR signaling pathway
• Enhances autophagy
• Reduces α-synuclein aggregation
• Mitochondrial membrane protection
• Blood–brain barrier permeable
• Senolytic activity
• Dissolvable in organic solvents (ethanol, DMSO, DMF)

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• Cognitive enhancement in Alzheimer's mouse models
• Multi-targeted therapeutic for Alzheimer's pathological features

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• Neuroprotective agent in Parkinson’s disease models
• Modulator of PI3K/Akt/mTOR signaling
• Autophagy enhancer
• Anti-inflammatory therapeutic candidate
• Antioxidant agent
• Mitochondrial protective agent
• Adjunct candidate to levodopa therapy
• Potential disease-modifying therapy in neurodegeneration

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Classification by use

• Chemicals used as cognitive enhancers
• Chemicals used in anti-Alzheimer's drug development

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• Chemicals used as neuroprotective agents
• Chemicals used as antioxidants

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A trustworthy factory and manufacturer

1. [Cite:1] HRMS-based profiling of metabolites, metal ions content and in-vitro cholinesterase inhibitory activities of Sonchus wightianus DC plant parts, Electronic Journal of Biotechnology, Volume 79, January 2026, 100702
2. [Cite:2] Targeting PI3K/Akt/mTOR with fisetin mechanistic and therapeutics insights for Parkinson’s disease, Letters in Drug Design & Discovery, 3 February 2026, 100319