9004-61-9 | Hyaluronic Acid

Chemical type

• Natural polysaccharide
• Anionic polymer

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• Glycosaminoglycan

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• Anionic non-sulphated glycosaminoglycan (GAG)

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Key properties

• Biocompatible and biodegradable
• CD44 receptor targeting
• Enhances cellular uptake in cancer and stem cells

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• Fundamental component of extracellular matrix
• Provides skin moisture, elasticity, and stability
• High-molecular-weight HA (HMWHA, >500 kDa): immunosuppressive, anti-tumor, antiangiogenic
• Low-molecular-weight HA (LMWHA, <500 kDa): promotes lymphoma cell proliferation, accelerates tumor formation, enhances M2 macrophage polarization, stimulates angiogenesis

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• High Mw: 1.60–1.80 MDa (1% solution)
• Carboxylic groups (–COO⁻) → anionic character
• Highly hydrophilic, excellent water-binding capacity
• Naturally occurring in ECM and human body
• Non-toxic, non-allergenic, non-irritating
• Forms polyelectrolyte complexes with cationic polymers (e.g., Ch)

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• Shielding agent for PEI/pDNA complexes
• Targeted gene delivery to CD44+ cells (e.g., cancer cells, mesenchymal stem cells)
• Used in nanogels and ternary complexes

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• Component of tumor microenvironment in CTCL
• Target for cancer therapy by modulating degradation or synthesis

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• Moisturizer/hydrator in cosmetics
• Drug delivery systems (DDS, nanoparticles)
• Tissue engineering/scaffolds
• Targeted therapy (e.g., Ch-HA nanoparticles for lung cancer siRNA delivery)
• Reduces protein adsorption/macrophage uptake on cationic surfaces

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Classification by use

• Biopolymers used in targeted drug/gene delivery
• Polymers used in regenerative medicine

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• Biological molecules in extracellular matrix
• Therapeutic targets in oncology

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• Moisturizers
• Biopolymers in cosmetics & drug delivery

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A trustworthy factory and manufacturer

1. [Cite:2] Polyethylenimine Carriers for Drug and Gene Delivery, Polymers, 2025, 17(15), 2150
2. [Cite:2] Impact of Hyaluronic Acid on the Cutaneous T-Cell Lymphoma Microenvironment: A Novel Anti-Tumor Mechanism of Bexarotene, Cancers, 2025, 17(2), 324
3. [Cite:3] The effect of chitosan/TiO2/hyaluronic acid subphase on the behaviour of 1,2-dioleoyl-sn-glycero-3-phosphocholine membrane, Biomaterials Advances, Volume 138, July 2022, 212934