69-53-4 | Ampicillin (C₁₆H₁₉N₃O₄S)

Chemical type

• Beta-lactam antibiotic

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• β-lactam antibiotic (broad-spectrum penicillin derivative)

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Key properties

• Molecular weight: 394.4 g/mol
• Inhibits bacterial cell wall synthesis
• Targets penicillin-binding proteins
• Moderate synergistic interactions with Terpineol (TER)

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• Small, hydrophilic molecule
• Broad-spectrum antibacterial activity
• Active against Gram-positive and Gram-negative bacteria
• Moderate transplacental transfer (~25% after 4 h in ex vivo model)
• Short half-life in pregnancy (~30 minutes)
• Primarily eliminated via renal excretion
• Low teratogenic risk
• ECOFF (epidemiological cut-off value):
  • 0.25 mg/L for Group B Streptococcus
  • 8 mg/L for Escherichia coli

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• Treatment of bacterial infections
• Combined antimicrobial studies

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• Intrapartum antibiotic prophylaxis
• Treatment of maternal bacterial infections during pregnancy
• Prevention of early-onset neonatal sepsis

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Classification by use

• Chemicals used as beta-lactam antibiotics
• Chemicals used to inhibit bacterial cell wall synthesis
• Chemicals used in combination antimicrobial research

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• Chemicals used as antibacterial agents
• Chemicals used for maternal infection therapy

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A trustworthy factory and manufacturer

1. [Cite:1] Terpineol enhances antibiotic effectiveness and reduces resistance in clinically relevant bacteria, Heliyon, Volume 11, Issue 15, October 2025, e43932
2. [Cite:2] Transplacental passage of ampicillin: Implications for antenatal therapy, Placenta, Volume 175, 6 March 2026, Pages 66-72