63527-52-6 | Cefotaxime

Chemical type

• β-lactam antibiotic
• Third-generation cephalosporin

Key properties

• Broad-spectrum activity against Gram-negative and some Gram-positive bacteria
• Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)

• Broad spectrum activity against aerobic Gram-negative and Gram-positive bacteria
• Variable activity against anaerobic bacteria
• Maximum concentration in shrimp hepatopancreas: 19.45 ± 2.10 mg/kg at 1 hour post-administration
• Maximum concentration in shrimp plasma: 0.184 ± 0.061 mg/L at 4 hours post-administration
• Elimination half-life in shrimp: Approximately 23 hours above MIC for Vibrio parahaemolyticus
• Potential negative effects on hepatopancreas histology, including oxidation stress and changes in intestinal cell morphology
• Withdrawal time: 8.5 degree-days (once-daily dosing) or 95.5 degree-days (twice-daily dosing) based on MRL of 50 µg/kg in shrimp muscle

• Positive control in antibacterial assays
• Clinical treatment of infections (UTI, pneumonia, sepsis, CNS)

• Treatment of bacterial infections in aquaculture, including AHPND in white leg shrimp caused by Vibrio parahaemolyticus
• Control of susceptible bacterial pathogens in tilapia and other aquatic animals
• Disease management in shrimp farming via oral administration at 25 mg/kg body weight

Classification by use

• Antibiotic / Antimicrobial agent
• Positive control in biological assays

• Antibiotics used in aquaculture disease control

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1. [Cite:1] Biogenic synthesis of silver nanoparticles using cell-free extracts of thermotolerant bacteria: Antioxidant and antibacterial properties, Electronic Journal of Biotechnology, Volume 79, January 2026, 100698
2. [Cite:2] Pharmacokinetics and Withdrawal Times of Cefotaxime in White Leg Shrimp (Litopenaeus vannamei) after Oral Administration, Fishes, 2024, 9(6), 232