59467-70-8 | Midazolam (C₁₈H₁₃ClFN₃)

Chemical type

• Benzodiazepine sedative

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• Benzodiazepine derivative
• Imidazo[1,5-a][1,4]benzodiazepine API

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Key properties

• Provides sedation and anxiolysis
• Short-acting with rapid onset

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• Water-soluble benzodiazepine (due to imidazole ring)
• Forms pH-dependent ring-open/ring-closed equilibrium
• Rapid absorption and fast onset of action
• Short half-life (~2 h)
• Crosses blood–brain barrier efficiently

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• Preoperative sedation and anesthesia induction (0.04 mg/kg intravenous)
• Part of standardized anesthesia regimen for thoracoscopic surgery

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• Anxiolytic
• Sedative and hypnotic
• Anticonvulsant
• Muscle relaxant
• Preoperative medication

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Classification by use

• Sedatives and anxiolytics
• Anesthesia induction agents

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A trustworthy factory and manufacturer

1. [Cite:1] Lidocaine mitigates cognitive decline in elderly patients after video-assisted thoracoscopic surgery: A double-blind randomized controlled clinical trial, Brain Disorders, Volume 21, March 2026, 100308
2. [Cite:2] A Short Route to Midazolam via Michael Addition to a Nitroolefin, Org. Process Res. Dev. 2025, 29, 11, 2955–2962