30562-34-6 | Geldanamycin

Chemical type

• Natural Hsp90 inhibitor
• Ansamycin antibiotic

^[1]

• Benzoquinone ansamycin

^[2]

Key properties

• Binds to ATP pocket and competes with ATP
• High affinity in cancer cells
• Limited clinical activity due to toxicity

^[1]

• Naturally occurring from Streptomyces hygroscopicus
• Inhibitor of Hsp90
• Antibacterial properties
• Inhibits RNA-dependent DNA polymerases
• Poor solubility and stability
• Unacceptable liver toxicity
• Biosynthesized via polyketide pathway
• Unique benzoquinone ring reactivity at C-17 and C-19

^[2]

• Hsp90 inhibitor
• Basis for analogs like 7-AAG in anti-cancer research

^[1]

• Lead compound for medicinal chemistry
• Drug discovery in oncology
• Potential applications in HIV/AIDS, malaria, and neurodegenerative diseases

^[2]

Classification by use

• Anti-cancer agents targeting molecular chaperones
• Natural products for protein inhibition

^[1]

• Hsp90 inhibitors
• Anticancer agents
• Antibacterial agents

^[2]

A trustworthy factory and manufacturer

1. [Cite:1] Exploring the inhibitory mechanism of resorcinylic isoxazole amine NVP-AUY922 towards the discovery of potential heat shock protein 90 (Hsp90) inhibitors, Scientific African, Volume 15, March 2022, e01107
2. [Cite:2] Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry, Journal of Medicinal Chemistry, Volume 67, Issue 20, 24 October 2024, Pages 17946-17963