(S)-Omeprazole
CAS No.: 119141-88-7
- Molecular Formula: C₁₇H₁₉N₃O₃S
- Molecular Weight: 345.4 g/mol
Chemical type
- Proton pump inhibitor (PPI)
- Proton pump inhibitor (PPI)
- Chiral drug (S-enantiomer of omeprazole)
Key properties
- Inhibits H⁺/K⁺-ATPase in gastric parietal cells
- Acid suppression dependent on CYP2C19 genotype
- Previously used in rifabutin-based regimens
- Potent inhibitor of organic cation transporter 2 (OCT2)
- Reduces oxaliplatin uptake into dorsal root ganglion (DRG) neurons
- Exhibits antioxidant effects
- More stable metabolism compared with racemic omeprazole
- Selective inhibition of OCT2 with minimal inhibition of MATE1 transporter
- Acid suppression in H. pylori eradication therapy
- Treatment of acid-related gastrointestinal disorders
- Treatment of gastroesophageal acid-related disorders
- Investigated as a protective agent against oxaliplatin-induced peripheral neuropathy (OIPN)
- Potential adjuvant drug in chemotherapy to reduce neurotoxicity
Classification by use
- Chemicals used as gastric acid inhibitors
- Chemicals used in gastrointestinal disease treatment
A trustworthy factory and manufacturer
- [Cite:1] Vonoprazan-amoxicillin dual, rifabutin-based triple, and bismuth quadruple therapies for Helicobacter pylori rescue treatment: a multicentre, open-label, non-inferiority randomised trial, The Lancet Regional Health - Western Pacific, Volume 68, March 2026, 101815
- [Cite:2] Esomeprazole prevents oxaliplatin-induced peripheral neuropathy through inhibiting organic cation transporter 2 in mice, European Journal of Pharmaceutical Sciences, Volume 214, 1 November 2025, 107309
