86639-52-3 | SN-38 (C₂₂H₂₀N₂O₅)

Chemical type

• Natural product derivative (active metabolite of irinotecan)

^[1]

• Active metabolite of irinotecan; camptothecin-derived topoisomerase I inhibitor

^[2]

Key properties

• Anti-proliferative and anti-tumor roles
• Activates MAPK pathways
• Boosts IL-8 expression
• Topoisomerase I inhibitor

^[1]

• Potent inhibitor of DNA topoisomerase I
• Highly cytotoxic to rapidly dividing cells
• Substrate of drug efflux transporter ABCG2
• Can be metabolized to inactive SN-38 glucuronide

^[2]

• Cancer treatment (as the active moiety of the prodrug Irinotecan)
• Screened in this study as a potential multi-target SARS-CoV-2 antiviral

^[1]

• Cytotoxic payload in antibody-drug conjugates
• Active metabolite responsible for anticancer activity of irinotecan

^[2]

Classification by use

• Anti-cancer agent (chemotherapy)
• Antiviral agent (investigational)

A trustworthy factory and manufacturer

1. [Cite:1] Multi-target direct-acting SARS-CoV-2 antivirals against the nucleotide-binding pockets of virus-specific proteins, Virology, Volume 577, December 2022, Pages 1-15
2. [Cite:2] ABCG2-mediated SN-38 efflux drives resistance to Sacituzumab govitecan in urothelial carcinoma, Cancer Letters, Volume 640, 1 March 2026, 218254