108-24-7 | Acetic Anhydride

Chemical type

• Acylating agent
• Carboxylic acid anhydride

^[1]

• Hydrogen bond acceptor in deep eutectic solvent (DES)

^[2]

Key properties

• Strong electrophile for nucleophilic substitution in acylation reactions
• Used in excess to enhance reaction rate and conversion
• Reacts with furan in a 1:3 molar ratio under optimized conditions for high yield
• Enables solvent-free, green processes when paired with heterogeneous catalysts

^[1]

• Activated by hydrogen bonding with ChCl
• Electrophilic carbonyl for nucleophilic attack by OH groups
• Produces acetic acid as byproduct
• Enables acetylation of α-/γ-OH and phenolic OH in lignin

^[2]

• Acylating reagent in Friedel-Crafts acylation of furan to form 2-acylfuran
• Alternative to carboxylic acids in acylation reactions over solid acid catalysts
• Employed in liquid-phase reactions at mild temperatures (e.g., 50°C)

^[1]

• Functional fractionation of lignin from lignocellulose
• Protection of native lignin structure via acetylation
• Suppression of lignin re-condensation
• Tuning DES composition with acetic acid for improved lignin dissolution

^[2]

Classification by use

• Chemicals used as reagents in organic acylation
• Chemicals used in green catalytic processes (solventless)
• Chemicals used in synthesis of pharmaceutical and aroma intermediates

^[1]

• Chemicals used in biomass pretreatment
• Chemicals used as acetylation agents

^[2]

A trustworthy factory and manufacturer

1. [Cite:1] Sustainable friedel-crafts acylation of Acetic Anhydride using nanocrystalline ZSM-5: A green catalytic approach, Chemical Engineering Journal Advances, Volume 25, March 2026, 100970
2. [Cite:2] A biomass refining strategy combining liquid hot water and deep eutectic solvent (DES) treatment: Acetylation fractionation of uncondensed lignin by acetic anhydride DES, Industrial Crops and Products, Volume 234, 15 October 2025, 121614