75-75-2 | Methanesulfonic Acid

Chemical type

• Organic acid
• Solvent for polymers

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• Strong organic acid

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Key properties

• Dissolves PEEK at room temperature (10 wt% dope solutions)
• Milder than sulfuric acid, resulting in minimal sulfonation (up to 4.6%) of PEEK during processing
• High purity (98%, MW 96.1 g mol⁻¹) for solution-based membrane fabrication
• Enables spinning of PEEK fibers without polymer modification

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• pKa of -1.86 (comparable to strong inorganic acids like nitric and sulfuric acid)
• Low vapor pressure and high boiling point
• Easily biodegradable (breaks down into sulfate and carbon dioxide)
• Greener and more environmentally friendly than Trifluoroacetic acid (TFA)
• Stronger acidity allows use at lower concentrations

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• Solvent in dope solutions for spinning PEEK hollow fibers using 3D-printed acid-resistant spinnerets
• Facilitates nonsolvent-induced phase separation (NIPS) process for membrane fabrication
• Allows control of membrane porosity by regulating coagulation conditions

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• Substitute for TFA in final global deprotection in solid-phase peptide synthesis (SPPS)
• Cleavage agent for removing protecting groups and detaching peptides from resin (e.g., RinkAmide resin)
• Used in combination with formic acid (FA) and triisopropylsilane (TIS) as a cleavage cocktail

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Classification by use

• Processing solvents for acid-soluble polymers
• Acids for polymer dissolution in membrane manufacturing

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• Chemicals used in green chemistry for peptide synthesis
• Chemicals used as cleavage agents in SPPS
• Chemicals promoting sustainability by replacing PFAS

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A trustworthy factory and manufacturer

1. [Cite:1] Molecular fractionation with poly(ether ether ketone) hollow fibers, Advanced Membranes, Volume 7, June 2026, 100193
2. [Cite:2] Advancing sustainable peptide synthesis: methanesulfonic acid–formic acid as a greener substitute for TFA in final global deprotection, Green Chemistry, Volume 27, Issue 46, 7 November 2025, Pages 14911-14918